Liver Cancer Increasing among People with HIV/HCV Coinfection


Hepatocellular carcinoma (HCC) is a growing problem among HIV positive people coinfected with hepatitis C virus (HCV) in Spain, and it is often diagnosed at a late stage when it is difficult to treat, researchers reported in the January 1, 2013, issue of Clinical Infectious Diseases.

Over years or decades, chronic HCV infection can lead to serious liver disease including cirrhosis and HCC, a form of primary liver cancer. Research indicates that liver disease progression occurs more rapidly in HIV/HCV coinfected people, especially those who are already HIV positive when they acquire HCV.

Nicolás Merchante from Hospital Universitario de Valme and colleagues conducted a study of the clinical and epidemiological characteristics of liver cancer among people with HIV. The analysis included all HIV positive people diagnosed with HCC at 18 hospitals in Spain before the end of December 2010.


"HCC is an emerging complication of cirrhosis in HIV-infected patients," the researchers concluded. "A sharp increase in its incidence has occurred in those also infected by HCV in the recent years."

"Unfortunately, HCC is frequently diagnosed at an advanced stage, and mortality continues to be very high, with no significant changes in recent years," they added. "Earlier diagnosis, which may allow potentially curative therapy, is necessary."



N Merchante, E Merino, J López-Aldeguer, et al. Increasing Incidence of Hepatocellular Carcinoma in HIV-Infected Patients in Spain. Clinical Infectious Diseases 56 (1):143-150. January 1, 2013.