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Acute Hepatitis C

Combining HCV Med Boceprevir with Boosted HIV Protease Inhibitors Can Lower Drug Levels

HIV/HCV coinfected people who take the HCV protease inhibitor boceprevir (Victrelis) for hepatitis C treatment along with a ritonavir-boosted HIV protease inhibitor may experience drug-drug interactions that reduce concentrations of both drugs to ineffective levels, Merck warned this week.alt

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European Study Does Not See Rapid Long-Term Liver Fibrosis in HIV/HCV Coinfected People

People who are already HIV positive when they acquire hepatitis C virus (HCV) may not experience unusually rapid liver disease progression over the long term, even though the fibrosis progression rate may appear high during the acute stage of infection, according to a European FibroScan study described in the February 15, 2012, issue of Clinical Infectious Diseases.alt

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EASL 2010: HIV/HCV Coinfected Patients with Acute Hepatitis C Are Equally Likely to Achieve Sustained Response with Interferon plus Ribavirin

HIV positive people with acute hepatitis C treated with pegylated interferon plus ribavirin, and HIV negative people treated with pegylated interferon alone, had a similar likelihood of achieving rapid virological response (RVR) at week 4 and sustained virological response (SVR) after completing treatment, according to findings presented at the 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) last month in Vienna. RVR was the best predictor of SVR, but HIV/HCV coinfected patients had larger HCV viral load reductions between weeks 4 and 12, suggesting that ribavirin promotes "third phase" viral decline.


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HCV Can Be Sexually Transmitted Between HIV+ Men

Hepatitis C virus (HCV) is transmitted by sex between HIV positive gay/bisexual men and sexual transmission is responsible for several local epidemics, including one in New York City, according to study findings published recently in the CDC's Morbidity and Mortality Weekly Report.alt

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Rapid Liver Fibrosis Progression and Successful Treatment of Acute Infection Suggest Benefits of Routine HCV Screening for HIV Positive Men

Researchers from Mt. Sinai School of Medicine presented data last week at the 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) in Boston that further characterize a cohort of HIV positive men with apparently sexually transmitted acute hepatitis C virus (HCV) infection. This group continues to experience more rapid than expected liver fibrosis progression. Hepatitis C treatment has been highly successful if started during the acute phase, but less so thereafter. The researchers recommended routine ALT and HCV antibody testing to allow for prompt treatment and to prevent liver disease progression.alt

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