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Inflammation & Immune Activation

CROI 2013: HIV+ Men at Increased Risk for Co-morbid Conditions Regardless of Age

 Men with HIV in a large cohort of U.S. veterans were more likely to develop cardiovascular disease, end-stage kidney disease, and certain cancers compared with HIV negative people, but not at earlier ages, according to a report presented at the 20th Conference on Retroviruses and Opportunistic Infections this month in Atlanta.

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CROI 2013: Can HIV Elite Controllers Benefit from Antiretroviral Treatment?

Elite controllers -- people who naturally maintain undetectable viral load without antiretroviral therapy (ART) -- experienced decreased levels of HIV genetic material and reductions in markers of inflammation and immune activation after starting experimental treatment, according to study findings presented at the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) last week in Atlanta.

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AIDS 2012: Studies Shed Light on Inflammation and Immune Activation in People with HIV

HIV and aging was a major medical themes at the recent XIX International AIDS Conference (AIDS 2012) in Washington, DC. A growing body of evidence indicates that inflammation and excessive immune activation contribute to cardiovascular disease and other non-AIDS conditions in people with HIV as they live to older ages, despite viral suppression on antiretroviral therapy (ART). Several studies presented at the conference looked at the causes and consequences of inflammation in this population. alt

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Low-Level HIV Viral Load Linked to Gut Leakage and Inflammation

Even low levels of HIV in the body are associated with microbial translocation, or leakage of bacteria from the gut, which can lead to excessive immune activation and inflammation, according to study published in the February 1, 2013, Journal of Acquired Immune Deficiency Syndromes

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AIDS 2012: Aspirin Dampens Immune Activation in HIV+ People on ART

Taking a daily aspirin reduces immune activation and activity of platelets -- the cells responsible for blood clotting -- which may help counteract the increased risk of cardiovascular problems among people with HIV taking antiretroviral therapy (ART), researchers reported at the XIX International AIDS Conference (AIDS 2012) last week in Washington, DC. alt

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