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New NRTI Microbicide Looks Promising in Lab

A novel vaginal microbicide gel containing the reverse transcriptase inhibitor IQP-0528 demonstrated good antiviral activity and safety in laboratory studies.

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CROI 2011: Safety and Acceptability of Tenofovir Gel and Tablets for Pre-exposure Prevention

A vaginal microbicide gel containing tenofovir was found to be generally well tolerated and acceptable by American and African women, though some study participants preferred taking a pill for HIV pre-exposure prophylaxis (PrEP), according to study findings reported this week at the 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011) in Boston. A related study found that the vaginal gel was not suitable for rectal use, and researchers are working on a more tolerable formulation.alt

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CAPRISA Microbicide Trial Shows Tenofovir Vaginal Gel Reduces HIV Transmission Risk by 39%

An antiretroviral vaginal gel containing tenofovir offered women moderate protection against HIV infection when administered before and after sex, according to findings from the CAPRISA 004 trial published in the July 19, 2010 issue of Science and announced at the XVIII International AIDS Conference (AIDS 2010). 

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FDA Grants Fast-track Status for Tenofovir Microbicide Gel for HIV Prevention

CONRAD, an agency spearheading research on microbicides to help prevent sexual transmission of HIV, last week announced that the U.S. Food and Drug Administration (FDA) has granted "fast track" status to enable quicker review of studies looking at 1% tenofovir gel, which reduced women's risk of HIV infection by 39% in the Phase 2 CAPRISA trial that garnered worldwide headlines at the International AIDS Conference (AIDS 2010) this summer in Vienna.

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Green Tea Compound in a Microbicide May Help Prevent HIV Entry into Cells

Since the start of the AIDS epidemic, researchers have sought women-controlled HIV prevention methods such as microbicide gels to reduce the risk of infection during sex. A wide variety of natural and manufactured chemicals have been tested as potential microbicides. Now, scientists report that a compound in green tea may help prevent HIV from attacking cells via semen.


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