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Treatment as Prevention

CROI 2014: No One with Undetectable Viral Load Transmits HIV in PARTNER Study

The second large study to look at whether people with HIV become non-infectious if they are on antiretroviral therapy (ART) has found no cases where someone with a viral load under 200 copies/mL transmitted HIV, either by anal or vaginal sex, researchers reported at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this week in Boston.

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PopART Study Will Look at HIV Treatment as Prevention on a Population Level

A new clinical trial (HPTN 071), co-sponsored by the U.S. National Institutes of Health (NIH) and the Bill & Melinda Gates Foundation, will assess whether offering HIV testing and early treatment on a door-to-door basis can help reduce incidence rates in Africa. The study -- which will involve 21 communities in South Africa and Zambia with a total population of 1.2 million -- is scheduled for completion in 2019.

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ICAAC 2012: HIV May Be Shed in Semen Even If Blood Viral Load Is Undetectable

About 8% of HIV positive gay and bisexual men intermittently had detectable HIV viral load in their semen even when their blood viral load was fully suppressed, researchers reported at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) this month in San Francisco. This is more than twice the rate seen in a similar study of heterosexual men. alt

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IAS 2013: No Increase in Risk Behavior among People Taking ART, Meta-Analysis Shows

One of the anxieties in relation to treatment as prevention is that it may discourage people with HIV from using condoms and other prevention methods. However, a meta-analysis has found no increase in risk-taking among people taking antiretroviral treatment, researchers reported at the 7th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2013) this week in Kuala Lumpur last week.

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AIDS 2012: HPTN 052 Continues to Show Clinical Benefits of Earlier Antiretroviral Therapy

The HPTN 052 trial, best known for showing that early antiretroviral therapy (ART) can dramatically reduce the risk of HIV transmission within serodiscordant couples, also found that early treatment reduces the risk of clinical events and death, though the benefit was largely driven by extrapulmonary tuberculosis, researchers reported recently at the XIX International AIDS Conference (AIDS 2012) in Washington, DC.

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