Other Infections
World TB Day: Find, Treat, and Cure Tuberculosis
- Details
- Category: Tuberculosis (TB)
- Published on Tuesday, 24 March 2015 00:00
- Written by HIVandHepatitis.com
In recognition of World TB Day on March 24, organizations released their latest figures on tuberculosis in the U.S. and worldwide and called for more action to improve access to testing, care, and treatment, while 2 recent studies offered promise for shorter therapy.
PaMZ Combination Regimen Shortens and Simplifies Tuberculosis Treatment
CROI 2015: High-Dose Rifampin Shortens Time to Tuberculosis Clearance
3/24/15
PaMZ Combination Regimen Shortens and Simplifies Tuberculosis Treatment
- Details
- Category: Tuberculosis (TB)
- Published on Tuesday, 24 March 2015 00:00
- Written by TB Alliance
An oral regimen combining the new drug pretomanid (PA-824) with the older moxifloxacin and pyrazinamide -- known as PaMZ for short -- has the potential to reduce the duration of treatment for drug-sensitive and even some drug-resistant tuberculosis (TB), according to findings from a study published in the March 17 online edition The Lancet. Nearly twice as many patients treated with the PaMZ regimen had undetectable TB in cultured sputum compared to those taking standard therapy.
CROI 2015: Screening May Miss Pre-cancerous Anal Lesions in Women with HIV
- Details
- Category: Human Papillomavirus (HPV)
- Published on Monday, 09 March 2015 00:00
- Written by Theo Smart
Existing algorithms to screen for anal cancer in women living with HIV could be missing many cases of anal high-grade squamous intraepithelial lesions (HSIL) -- abnormal tissue changes that may be a precursor to invasive anal cancer -- according to a study reported at the recent 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle.
CROI 2015: High-Dose Rifampin Shortens Time to Tuberculosis Clearance
- Details
- Category: Tuberculosis (TB)
- Published on Tuesday, 24 March 2015 00:00
- Written by Liz Highleyman
A combination regimen containing high-dose rifampin (also known as rifampicin) was associated with faster tuberculosis bacteria culture conversion in people with drug-sensitive TB, but moxifloxacin and the experimental drug SQ109 showed no benefit compared to standard therapy, according to results from a study presented at the recent 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle.
CROI 2015: XDR-TB in South Africa is Largely Spread Person-to-Person, Not By Treatment Failure
- Details
- Category: Tuberculosis (TB)
- Published on Thursday, 05 March 2015 00:00
- Written by Keith Alcorn
The vast majority of people with extensively drug-resistant tuberculosis (XDR-TB) diagnosed in the world’s most extensive outbreak have acquired their infection from another person, not as the result of the failure of treatment for multidrug-resistant strains of tuberculosis (MDR-TB), N. Sarita Shah reported at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) last week in Seattle.
March 24 Is World TB Day
- Details
- Category: Tuberculosis (TB)
- Published on Monday, 23 March 2015 00:00
- Written by HIVandHepatitis.com
March 24 is World TB Day, an opportunity to raise awareness about tuberculosis (TB) and the need for expanded testing and treatment worldwide. The World Health Organization's theme for 2016 is "Unite to End Tuberculosis". Ending TB by 2030 is a target of the United Nations' Sustainable Development Goals.
CROI 2015: XDR TB Transmission in High-HIV-Prevalence Settings [VIDEO]
- Details
- Category: Tuberculosis (TB)
- Published on Thursday, 05 March 2015 00:00
- Written by Gregory Fowler
Most people with extensively drug-resistant tuberculosis (XDR-TB) in South Africa acquired the infection through person-to-person transmission -- including transmission in community settings as well as in hospitals -- rather than due to failure of treatment for multidrug-resistant TB, according to a report at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) last week in Seattle.
Isoniazid Alone Prevents TB in People with Advanced HIV, Urine Test May Cut Mortality
- Details
- Category: Tuberculosis (TB)
- Published on Monday, 23 March 2015 00:00
- Written by Liz Highleyman
Using isoniazid alone to prevent the development of active tuberculosis (TB) in people with advanced HIV disease was equally effective and better tolerated than a common 4-drug empirical TB regimen, according to a study published in the March 19 edition of The Lancet in advance of World TB Day. Another study in the same issue found that a new inexpensive urine test has the potential to help reduce TB-related mortality by enabling faster treatment.
CROI 2015: Early ART and Isoniazid Preventive Therapy Reduce Risk of Illness and Death in Africa
- Details
- Category: Tuberculosis (TB)
- Published on Tuesday, 03 March 2015 00:00
- Written by Keith Alcorn
Starting HIV treatment at a CD4 cell count above 500 cells/mm3 reduced the risk of serious illness, including tuberculosis (TB), and death by 44% when compared to starting treatment according to World Health Organization (WHO) guidelines, results from the 7-year Temprano study show. The findings were presented on at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) last week in Seattle. The study also found that a 6-month course of isoniazid preventive treatment (IPT) reduced the risk of developing TB by 35%.
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